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There is an urgent need for investment in long Covid clinical trials, and in decentralized clinical trials like this one in particular, says Hannah Davis, cofounder of the Patient-Led Research Collaborative, a long Covid research and advocacy group

Many individuals with obesity already have poor diet quality and may already be vulnerable to nutrient gaps before the medication is ever started

Our study followed the target trial emulation framework, incorporating eligibility criteria, treatment strategies, assignment procedures, follow-up period, outcome, causal contrasts, and analysis plan aligned with an ideal randomized controlled trial, which we then emulated using observational data (Table S1)

This estimate does not include rebates, which Medicares actuaries estimated to be 31.5% overall in 2022 but could be as high as 69% for Ozempic, according to one estimate