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Typical starting doses include: Semaglutide (Wegovy): 0.25 mg weekly Tirzepatide (Zepbound): 2.5 mg weekly These starting doses were studied in programs such as the STEP and SURMOUNT trials and were gradually increased to achieve validated metabolic outcomes

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Keeping Rybelsus in its original bottle helps protect the tablets from moisture

Diabetologia 2011

After 40 weeks, tirzepatide significantly outperformed placebo in both glycemic control and weight loss