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The comparison between tirzepatide and next-generation triple agonists like retatrutide is relevant for researchers tracking the evolution of this field

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At minimum, drop one dose level from your previous maintenance dose

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The approved regimen begins at 2.5 mg weekly for four weeks, then increases to 5 mg weekly for four weeks, with further escalations to 7.5 mg, 10 mg, 12.5 mg, and a maximum of 15 mg weekly, each maintained for at least four weeks

GLP-1s are known to reduce both fat and muscle mass and discontinuation typically results in weight regainprimarily as fat massresulting in a less healthy body composition compared to treatment initiation