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During pregnancy and lactation, plasma leptin levels reduce by 40% for metabolic adaptions when high PRL levels, leptin resistance, hyperphagia (69), increased body weight coincide to facilitate nutrient shift to offspring (70)

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You should contact your GP or prescribing clinician if you experience: Severe or persistent symptoms: Severe abdominal pain , particularly if it's constant or worsening Persistent vomiting that prevents you from keeping down fluids or medications Severe diarrhoea lasting more than 48 hours or occurring more than 6 times daily Signs of dehydration including dark urine, dizziness, extreme thirst, or reduced urination Blood in vomit or stools Unexplained weight loss beyond what's expected from the treatment Symptoms suggesting serious complications: Severe upper abdominal pain radiating to the back , which could indicate pancreatitis (a rare but serious side effect of GLP-1 medications) Sudden, severe pain in the upper right abdomen , possibly radiating to the shoulder, which could indicate gallbladder disease (a known risk with weight loss and GLP-1 medications) [2] Persistent nausea with fever Yellowing of skin or eyes (jaundice) Severe constipation lasting more than a week despite management strategies For severe symptoms, contact NHS 111 or seek urgent care if you cannot reach your GP promptly, especially for suspected pancreatitis, severe dehydration, or gallbladder inflammation

You can read the full article at Serotonin (5-HT) is an important neurotransmitter associated with psychiatric disorders, but its precise role in behavior has been poorly understood due to a lack of methods to specifically target adult brain serotonin synthesis