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The clinical philosophy emphasizes identifying each persons optimal therapeutic window that provides maximum benefits with manageable tolerability

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[ 45 , 46 , 47 , 48 ] This resistance occurs through the support of cancer stem cell populations and modifications in drug transport mechanisms, presenting a substantial challenge in TNBC treatment strategies

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9 In UKPDS 34, the advantages and disadvantages of metformin for intensive glycemic control in overweight patients newly diagnosed with T2DM were specifically examined