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Existing therapeutic options fail to halt neurodegeneration by modulating metabolic dysfunction, leaving the neuroprotective clinical needs largely unmet

drugs like glp 1 GLP-1 Drug Savings: A Complete Guide for How to Save on Ozempic, Wegovy, and More GLP-1 Medications for Weight Loss:

doi: 10.1002/j.1536-4801.2006.tb00012.x

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liraglutide crosses poorly and showed limited effects

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Orlistats main drawback is digestive: because the unabsorbed fat has to go somewhere, side effects like oily or loose bowel movements are common (especially after fatty meals)

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To fully understand the differences in the mechanisms and long-term effects of GLP-1RAs on the retina, a combination of clinical trials and mechanism studies is necessary (85)

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Recently, the first clinical trial to show the benefit of AOMs in ORC outcomes was published

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