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Description
Existing therapeutic options fail to halt neurodegeneration by modulating metabolic dysfunction, leaving the neuroprotective clinical needs largely unmet

doi: 10.1002/j.1536-4801.2006.tb00012.x

liraglutide crosses poorly and showed limited effects

Orlistats main drawback is digestive: because the unabsorbed fat has to go somewhere, side effects like oily or loose bowel movements are common (especially after fatty meals)

To fully understand the differences in the mechanisms and long-term effects of GLP-1RAs on the retina, a combination of clinical trials and mechanism studies is necessary (85)

Recently, the first clinical trial to show the benefit of AOMs in ORC outcomes was published
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