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Unrealised Expectations Despite progress, several anticipated 2025 milestones did not come to fruition: Regulatory progress stalled: FDAs obesity drug guidance, published in draft form in January 2025, remains unfinalised, whilst EMA has yet to update its 2016 guideline

Further trials are needed to investigate whether GLP-1 agonists, and particularly with more effective weekly agents (i.e

GLP-1 is a natural hormone released by the gut after eating

But from 2030, Pfizer could emerge as a credible Top-3 obesity player if both the injectable and oral combo strategies succeed

GLP-1 medications like semaglutide and tirzepatide show mixed effects on gastrointestinal symptoms, with potential benefits for some IBS patients but also the risk of worsening symptoms in others

My waistline is back to normal
