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Based on glycemic response and tolerability, the dose may be increased to 1 mg or 2 mg weekly

doi: 10.1016/j.jep.2014.09.049

Even without such combinations, alcohol can irritate the gastrointestinal tract, and since nausea, vomiting, and gastrointestinal discomfort are among the most commonly reported side effects of GLP-1-based therapies, alcohol consumption may worsen these symptoms

The treatment of type 2 diabetes with GLP-1 has been a proven method since 2005

91 Although these studies were conducted in patients with normal LV systolic function, it is reasonable to imagine a similar effect in HFrEF patients as well, with obvious implications for daily clinical practice