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Another study [10] was conducted in 20 healthy volunteers (half of them treated with GLP-1RAs) and assessed for RGC after 8 hours of fasting
These mechanistic insights are supported by independent studies showing reduced first-phase insulin secretion in carriers of the SLC30A8 Arg325Trp variant and impaired GLP-1-stimulated insulin release in KCNJ11 loss-of-function mutants
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Paired with the right diet and exercise, half the participants lost 15% of their body weight, and some even lost 20% of their body weight
