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The report also noted that a large Phase IIb trial (ZUPREME-1) is underway with enrolment expected to be completed in the first half of 2025 and that a second Phase IIb trial (ZUPREME-2) is planned to evaluate petrelintide in individuals with type 2 diabetes

Given that GLP-1 biology is complex and may involve several parallel mechanisms with or without transmembrane receptors (31) and distinct metabolites (32), we chose to next focus on the direct actions of the single metabolite GLP-1(2836) using in-depth in vitro studies into its cellular and molecular actions

Managing side effects Another reason Yusufov believes clinical support is essential for people taking GLP-1 medications for weight loss is to help support patients through common side effects such as constipation and nausea/vomiting

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Additionally, blockade of GLP-1Rs in the LS with exendin-9 alone enhanced sucrose and oil intake indicating a physiologic role for these neurons to suppress food intake