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The implications of centrally produced, neuromodulatory GLP-1 in the context of GLP-1RAs are uncertain, as the degree to which signals from pre-proglucagon neurons/endogenous GLP-1 system and GLP-1RA activity converge on shared downstream targets is unclear 6 and may in fact occur independently 7
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However, this represents a double-edged sword
On top of that base, the index adds points for tables and repeating lists, bundled instruction pages, and dense page layouts capturing difficulty the base alone can miss
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