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doi: 10.2147/OTT 72 Bjerre KnudsenLMadsenLWAndersenSAlmholtKde BoerASDruckerDJet al

These medications slow gastric emptying, enhance insulin secretion in response to glucose, and signal satiety to the brain's appetite centers

This dual mechanism may explain why retatrutide achieves weight loss that approaches bariatric surgery outcomes without the plateau that characterizes GLP-1-only therapies

These individuals could also benefit from GLP-1 medications, but may face additional challenges in accessing them

Because of how potent these combined effects are, microdosing is strongly recommended over jumping straight to standard clinical doses

However, the strategic use of language, imagery, and promotional tactics in these ads raises essential questions about the commercial determinants of health (CDOH)