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70 16% of the baseline level), and (4) diuretic and natriuretic responses to intravenous infusion of GLP-1 were blunted (urine flow 53.4 4.3 vs

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We report that dual blockade with our fully human GDF8 and ActA blocking antibodies during GLP-1 RA-treatment of obese mice and NHPs preserves lean mass, while also increasing fat loss and improving metabolic measures