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Because the prevalence of CVD in the population with T2DM is around 32% [33], at least one fourth of the average patient with T2DM is possible a candidate for the use of the GLP-1RA, or sodium-glucose transporter-2 inhibitors [34], to improve the MACE outcome

The purpose of this review is to compare the clinical trial and real-world effectiveness data of second-line therapy with SGLT2-I and GLP-1RA related to A1c reduction, weight loss, cost-effectiveness, and safety in patients with T2DM

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The same paper also included a nested case-control component of 120,054 patients with T2DM followed for 7.4 years and observed a lower association between dementia and exposure to GLP-1RAs compared with other antidiabetics 39