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Rather than reproducing the peptides sprawling footprint, the small molecule tucks into a compact, mostly hydrophobic pocket in the upper portion of the helical bundle

The intermediate was finally reacted with the appropriate amine-containing drug (+)-MK-801 (2,2-diphenyl-1-amine

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Briefly, the Nb35 target gene was transformed in BL21 (DE3) and grown in a TB culture medium with 100 g/mL ampicillin, 2 mM MgCl 2 and 0.1% (w/v) glucose at 37C, 180 rpm

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The study has not been peer reviewed