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In den sogenannten STEP-Studien, einer Reihe global angelegter klinischer Studien zur Bewertung von Sicherheit und Effizienz von Semaglutid, erzielte der Wirkstoff in der zugelassenen 2,4-Milligramm-Dosis nach 68 Wochen bei bergewichtigen oder adipsen Menschen mittlere Gewichtsverluste von 14,9 bis 17,45%