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The main takeaway

Moreover, administration of exendin-4 led to a reduction in 5-HT and 5-HIAA, whereas GLP-1R antagonists increased the levels of serotonin and its metabolites [56]

Nasser Nasseri, MD at Noor Medical Spa, Explains When to Choose It Over Ozempic Is Semaglutide GLP-1 the same as Ozempic for weight loss

Since gastrointestinal adverse effects are rarely severe and tend to diminish over time, they would therefore not be expected to cause a barrier to initiating and continuing treatment for most patients