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This FDA-approved treatment works by targeting the hormone glucagon-like peptide-1 (GLP-1), which regulates appetite and calorie intake

However, large human data reviews, including a 2025 JAMA Network Open study, found no clear link between GLP-1 use and overall cancer risk

[42] found that semaglutide significantly reduced the risk of new or worsening nephropathy (HR 0.64, 95% CI 0.460.88) and macroalbuminuria (HR 0.54, 95% CI 0.370.77) in patients with overweight or obesity (HR 0.89, 95% CI 0.820.98), and that conclusion is based on the SUSTAIN-6 study, for patients with type 2 diabetes