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Description
The main pharmacological efficacy biomarkers determined in Phase 3 studies for GLP-1 RAs are summarized in Table 4
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Research indicates that GLP-1s may have beneficial effects in those with knee osteoarthritis, including reduced pain and fewer joint replacements by reducing weight and inflammation

Renal pathways excrete GLP-1 analogs, and clinicians do not adjust dosages for clients with mild renal or hepatic impairment (6)
Diagnosis of acute pancreatitis typically requires at least two of the following three criteria (Atlanta classification): characteristic abdominal pain, serum lipase or amylase elevated to at least three times the upper limit of normal, and imaging findings consistent with pancreatic inflammation
95% CI 0.93, 1.01), MACE (HR 0.95
