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Our study builds upon this by demonstrating that the magnitude of CV death reduction with semaglutide is comparable between T2D patients and overweight or obese patients without T2D, extending to MACE, expanded MACE, and nonfatal stroke

Most fatigue during GLP-1 therapy stems from reduced calorie intake or rapid weight loss rather than the medication directly

Clinically proven to result in a 15-20% reduction in body weight when combined with lifestyle modifications, semaglutide offers a significant advantage for those pursuing weight management

Trial investigators emphasised that supportive care strategies including dietary adjustments, hydration, and use of standard medications were sufficient to manage these milder GI issues

How should researchers compare variants

These medications enhance your body's natural insulin secretion when blood glucose rises, which can lead to faster blood sugar spikes followed by sharper drops