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Abbreviations ASCVD: Atherosclerotic cardiovascular disease CHD: Coronary heart disease CI: Confidence interval CVD: Cardiovascular disease CVOT: Cardiovascular outcome trial DPP-4i: Dipeptidyl peptidase-4 inhibitor GLP-1: Glucagon-like peptide 1 GLP-1R: Glucagon-like peptide 1 receptor HbA1c: Glycated haemoglobin HR: Hazard ratio LDL: Low-density lipoprotein MACEs: Major cardiovascular events NO: Nitric oxide OR: Odds ratio PIONEER: Peptide Innovation for Early Diabetes Treatment ROS: Reactive oxygen species SC: Subcutaneous SNAC: Sodium N -[8-(2-hydroxybenzoyl)amino] caprylate TAGs: Triacylglycerols TGs: Triglycerides T2DM: Type 2 diabetes mellitus VLDL: Very-low-density lipoprotein References Litwak L, Goh SY, Hussein Z, Malek R, Prusty V, Khamseh ME

Key Takeaways Recent clinical trials have established glucagon-like peptide-1 receptor agonists (GLP-1 RAs) as a major breakthrough in the management of nonalcoholic steatohepatitis (NASH)

PlexusDx supports whatever monitoring your healthcare team recommends

However, these non-serious ADRs are tolerable in individuals with diabetes and obesity [8,9,10]

Mounjaro is FDA-approved to treat type 2 diabetes alongside diet and exercise

If you do experience constipation, consider magnesium supplements or a fiber supplement