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The jump from 4mg to 8mg added another 5.7 percentage points, reaching 22.8%

Atherosclerotic plaque fissuration and clinical outcomes in Pre-diabetics vs

Others, like NAION, may cause irreversible vision loss

Consequently, once-daily subcutaneous administration of liraglutide 3.0 mg was developed for the treatment of obesity [21] and once-weekly subcutaneous administration of semaglutide 2.4 mg is currently being investigated in phase III trials for this indication [22]

Future generations of incretin agonists may be able to maintain the reduction in blood glucose and body weight while minimizing these off-target effects

Though both start at an initial dose of 0.25mg/week, the target dose for Wegovy is higher, usually at 2.4mg/week, so as to amplify the weight loss benefits
