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Most people report appetite suppression returning by week 2-3 on tirzepatide, even at the 2.5 mg dose, because the GIP receptor activation adds effects that semaglutide alone could not provide

Diabetes, obesity & metabolism, 25(3), 664674

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Bkdal T.A., Thomsen M., Kupov V., Hansen C.W., Anderson T.W

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A patient starting at 250 pounds may lose 50-55 pounds (22%), while someone beginning at 180 pounds might lose 25-30 pounds (15-17%) on the same doseboth represent equivalent percentage weight loss but different absolute numbers

If a patient's weight loss starts affecting cardiovascular markers or blood sugar, their One Medical provider sees that in real time not six months later at an annual checkup