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Preclinical studies have clearly demonstrated that GLP-1RAs effectively reduce hepatic macrophage infiltration and suppress expression of TNF- , IL-6, and other pro-inflammatory mediators in animal models of MASLD (21, 22)

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Taken together, GLP-1 RAs may have cytoprotective effects through modulating intracellular calcium concentrations via L-type voltage-dependent calcium channels and NMDA receptors