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Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential

Robert Kushner: Two messages

Despite likely being a similar tier as GLP-1 RAs and SGLT2is for many patient insurances, this elevated AWP is important to note for patients with co-insurances, deductibles, the Medicare coverage gap, patients without insurance, and for the total cost of healthcare

Initiation only builds tolerance during weeks 14

Its development is unusual among modern peptides in that the compound is the end point of a documented, four-decade scientific chain: from the sequencing of a gene, through the identification of a physiological hormone, to a specific set of chemical modifications engineered to solve a well-defined pharmacokinetic problem

XERF, which stands for Extreme Radiofrequency, is a non-surgical skin tightening treatment that uses controlled radiofrequency energy to heat the deeper layers of the skin