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Semaglutide is not appropriate for people with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2

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Author: HealthRX.com Editorial Team Medically reviewed by: the HealthRX.com Medical Team Last clinical review: May 2026 Compounded semaglutide is not FDA-approved

Common: nausea, diarrhea, vomiting, indigestion, constipation Other possible: burping, fatigue, stomach pain, hair loss, injection site reactions, dizziness Serious (seek immediate care): Allergic reactions: hives, throat/tongue swelling, breathing difficulty Thyroid tumors: neck lump, hoarseness Pancreatitis: severe abdominal pain, vomiting Kidney injury: dehydration signs, low urine output Gallbladder issues: upper abdominal pain, fever Hypoglycemia: shakiness, confusion when combined with insulin or sulfonylureas Diabetic retinopathy worsening: vision changes Depression or suicidal thoughts Is there a Boxed Warning with Zepbound

The most frequent serious adverse events were infections and cardiac- and kidney-related disorders

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