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Research suggests roughly 30% of weight lost on GLP-1 therapy comes from lean mass, with significant variability between studies. With adequate protein intake and consistent resistance training, that proportion can be reduced

"These discounts might seem small individually," notes Kelsey Mackley, "but together they can add up to significant savings over the life of your policy

[19] A 2011 Cochrane review showed a HbA1c reduction of 0.24% more with liraglutide 1.8 mg compared to insulin glargine, 0.33% more than exenatide 10 g twice daily, sitagliptin and rosiglitazone

An alternative, more effective strategy might involve delaying patient enrollment initially, accumulating stock, and then expanding the patient pool in later periods

Yen FS, Hsu CC, Wei JCC, Tsai FJ, Huang Y, Yu TS, et al

"Despite the widespread morbidity and mortality burden of HFpEF, current treatment options are limited," said corresponding author Nils Krger, MD, of the Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Womens Hospital, a founding member of the Mass General Brigham healthcare system