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Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

Constipation , diarrhea , fatigue , headaches , and dizziness are all reported

[6] [18] The standard titration schedule begins at 0.25 mg once weekly for four weeks (an initiation dose not intended for glycemic control), followed by escalation to 0.5 mg weekly

Therefore, precise control of the activation or repression of GLP-1 signaling in different body sites will be essential to develop an effective treatment with minimal off-target effects

Which, at a high level, increases energy expenditure

This happens because of the compounding effects of both hypothyroidism, the second entry on this list below, and the side effects of semaglutide