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This accolade is per the company's published materials

Among them, retatrutide has shown significant clinical advantages in phase II clinical trials, reducing the weight of obese patients by up to 24.2% in 48 weeks and lowering the HbA1c of type 2 diabetes patients by 2.2% in 36 weeks ( 3.3.2 Regulation of hepatic lipid metabolism Triple receptor agonists exhibit promising synergistic effects on hepatic lipid metabolism, a central pathological feature in MASLD

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This sympathetic activation can lead to severe health issues such as sodium retention, increased cardiac output and heart rate, elevated vascular resistance, activation of the renin-angiotensin system, high blood pressure, enhanced oxygen consumption, sudden death, insulin resistance, increased non-esterified fatty acids, diabetes, dyslipidemia, and congestive heart failure (6)

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