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In the cardiac magnetic resonance (CMR) sub-study of the SUMMIT trial, in comparison with the placebo, the treatment of obesity-related HFpEF with tirzepatide can lead to a reduction in LV mass and pericardiac adipose tissue

Rapid weight loss on a GLP-1 can take lean mass along with fat, and a compressed eating window shrinks the time you have to eat protein

[DOI] [PubMed] [Google Scholar] [25].Xu J, Wei G, Wang J, et al

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Taking the GLP-1R agonist was associated with nausea, diarrhea, and vomiting, but not with hypoglycemia (208)