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Children under age 18: Semaglutide has not been studied in children so it is unknown whether it is effective and safe in young people

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While GLP-1 can bind to receptors on circumventricular regions (e.g., area postrema), it is yet unclear to what extent gut-derived or brain-derived GLP-1 contribute to central GLP-1R activation (Trapp & Brierley, 2022)