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They had a baseline glycated hemoglobin (HbA1c) level between 7.5% and 10.5% (58-91 mmol/mol), a body-mass index of 25 kg/m2 or greater, and established cardiovascular disease or a high risk of cardiovascular events

The cell-specific expression of Gcg is orchestrated by a series of homeodomain proteins that bind to specific cis-acting elements in the Gcg promoter and/or enhancer region to either stimulate or inhibit Gcg promoter activity [94,[98], [99], [100]]

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