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I think knowing that going in, while understanding the current side effects of GLP-1s, is your best tool for making a decision about the medication. Published August 2025

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Speculatively, these effects may be highly transient or potentially compensated for with time, as no differences in cumulative body weight or body composition were observed (Sisley et al., 2014)

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People who have a personal or family history of medullary thyroid cancer or a condition called multiple endocrine neoplasia syndrome type 2 (MEN 2) should not take semaglutide

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