glp 1 substance abuse GLP-1s like Ozempic transformed weight loss and diabetes. Is addiction next? : NPR GLP-1 medications are getting attention

The data showed that exendin-4 treatment elevated the levels of p-protein kinase B (Akt) and B-cell lymphoma 2 (Bcl-2) and suppressed the level of Bax, which indicated a lower level of cell apoptosis

Specifically, antagonizing NMDA receptors in the brainstem has been associated with an increase in short-term food intake 6,7

N Engl J Med 375 , 311322, (2016)

This Is What I Already Knew (and So Did You) In Chapter 2 of my book, I talk about the four biological systems that create genuine urges for food

Co-infusion of GLP-1 and GCG has been shown to reduce glucagon-induced hyperglycemia, lower blood glucose levels, suppress food intake, and enhance energy expenditure in both diabetic obese mice and healthy human volunteers [78]

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators