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IBD associated diarrhea is linked to significantly reduced luminal and Na + /H + exchange activity and/or levels in distal intestine 5,6 SLC26A3 (DRA, down regulated in adenoma), is the key Cl /HCO 3 exchanger in mammalian intestine and has recently been identified as a novel risk factor for UC development

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We discovered that platypus and echidna express a single GLP-1 peptide in both intestine and venom

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