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While many on the medications said they have changed their lives for the better, some experts are concerned about the long-term effects of these relatively new drugs. Once its approved on the market, theyll collect data for like, a year, and thats it, said Alexis Moore, assistant professor of Physician Assistant studies and a clinician by training

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The hepatic TGF-/Smad signaling pathway was downregulated by SEMA treatment, while sirtuin 1 (SIRT1) content and phosphorylated AMP-activated protein kinase (p-AMPK) expression were upregulated