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3.1.2 Exenatide As the first GLP-1R agonist approved for T2DM, EX is a new class of compound and a synthetic product of exendin-4, which is a compound naturally derived from the Gila monster and has multiple hypoglycemic mechanisms: inhibiting of glucagon release from cells, slowing of gastric emptying, decreasing appetite and increasing glucose-dependent insulin secretion (12, 46, 47)

aAlbuminuria, chronic kidney disease, retinopathy, left ventricular hypertrophy, bAge (men 45 years, women 55 years), smoking, obesity, dyslipidemia, family history of early-onset coronary heart disease

However, large cardiovascular safety studies did not confirm this association, warranting further investigation

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