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As patents are provided with 20 years of protection from the date of filing once granted, these patents should technically expire on March 20, 2026 (see Figure 8)

For example, a 72-week study of adults with obesity or overweight found that people lost 20.2% of their body weight on tirzepatide vs

It can elevate blood pressure and heart rate, and it can make people feel irritable

The same review notes that its prodrug mechanism creates more predictable and consistent plasma concentrations than traditional amphetamine formulations

Headaches tied to dose increases usually last 1-3 days and improve with adequate hydration and rest

Two factors compound: drug exposure scales with body weight (lighter body = more drug per pound), and physiological response varies by metabolic and cardiovascular phenotype