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This was a specific and unexpected side effect, reported by a large percentage of patients, and, again, less likely to be a placebo effect

Acute peripheral or central GLP-1 receptor stimulation increases heart rate and blood pressure

NICE guidance (NG28) recommends GLP-1 receptor agonists as treatment options for adults with type 2 diabetes when metformin and other oral therapies have not achieved adequate glycaemic control, or when there are specific clinical considerations such as significant obesity or high cardiovascular risk

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Nausea can potentially be prevented by making dietary changes, such as eating smaller and more frequent meals, eating slowly, avoiding food with high fat content, and drinking clear or ice cold drinks

While research continues, existing patches have not demonstrated therapeutic efficacy comparable to injections in clinical trials