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Studies in humans In response to the increasing reports of GLP1RA exposure in pregnancy, several observational studies (summarised in Table 3) have been conducted screening large databases of pregnancy records to uncover the impact of perinatal GLP1RA exposure on fetal outcomes including congenital malformations and pregnancy loss
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Consistent with this, plasma levels of GLP-1 rapidly increase in healthy humans upon direct administration of carbohydrates or lipids into the ileum [210]

Cardiovascular Impact: The Glucagon receptor activity has been associated with transient increases in heart rate