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Unlike Rybelsus, which was the first oral GLP-1 medication but still a peptide, orforglipron is the first non-peptide oral GLP-1 receptor agonist

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According to a new study published in Diabetes, Obesity and Metabolism, GLP-1 drugs made food taste sweeter and saltier, which led to reduced appetite, increased satiety, and fewer food cravings among those who used the drugs