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The KRESCENT program is co-sponsored by the Kidney Foundation of Canada, the Canadian Society of Nephrology, and the Canadian Institute of Health Research (CIHR)

Francesca Tavella and Neil Davies were employees of Adelphi Values PROVE at the time of the conduct and reporting of this research

Pharmacovigilance and signal detection FAERS semaglutide disproportionality (broad): A FAERS-based disproportionality analysis of semaglutide reports through mid-2023 identified multiple unexpected adverse event signals and explicitly notes that some signals were not mentioned in the drug insert, including polycystic ovaries. The analysis highlights typical spontaneous-reporting limitations (missing age, outcome data)

Actual Medication Cost Per Dose Approximate Compounding Costs: While providers dont break this down, approximate pharmaceutical costs: Per Dose (Wholesale to Pharmacy): 2.5 mg dose: ~$15-25 5 mg dose: ~$25-40 7.5 mg dose: ~$35-55 10 mg dose: ~$45-70 12.5 mg dose: ~$55-85 15 mg dose: ~$65-100 Monthly Medication Cost (4 doses): 2.5 mg weekly: ~$60-100/month 5 mg weekly: ~$100-160/month 7.5 mg weekly: ~$140-220/month 10 mg weekly: ~$180-280/month 12.5 mg weekly: ~$220-340/month 15 mg weekly: ~$260-400/month Additional costs for providers: Medical consultation/oversight: ~$50-100/month allocated Supplies (syringes, sharps, pads): ~$10-20/month Shipping and handling: ~$15-25/month Customer support and operations: ~$30-50/month Platform/technology costs: ~$20-40/month Total provider cost: ~$250-400/month at maximum doses Provider pricing of $349-$699/month represents reasonable to premium margins over actual costs

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[DOI] [PubMed] [Google Scholar] 27.Orforglipron, an oral non-peptide glucagon-like peptide-1 receptor agonist, improves markers of -cell function and insulin sensitivity in type 2 diabetes