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The highly expressed protein convertase Furin inhibits intestinal epithelial cell damage in a rat model of UC by activating the Nrf2Gpx4 pathway, thus alleviating the symptoms of UC

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There is no approved medication for it, and treatment mostly involves compression therapy

Furthermore, in humans, a study using a uniformly labeled glucose tracer found that glucose absorption was increased after RYGB, and this rapid absorption was associated with the exaggerated release of insulin and GLP-1 (51)

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Then, GPR43 (50 nM), GPR109a (50 nM), and NC siRNA (50 nM) were delivered into the HepG2 cells (~40% confluent density) and cultured in Opti-MEM (Gibco) for 6 h, after which the transfection mixture was replaced with normal medium