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Cocaine Only limited clinical evidence is available for GLP-1RAs in cocaine misuse: a small ( N = 13) proof-of-concept trial across 2 days showed that exenatide compared with placebo did not reduce the number of self-administered cocaine infusions 115 , while a case series of 3 individuals with cocaine-use disorder highlighted the feasibility and safety of using the same drug over 6 weeks, although no efficacy measures were reported 116

Standing up too quickly or changes in posture can then trigger orthostatic hypotension, a condition where dizziness follows sudden position changes

This entire process significantly improved my mood and mental health, allowing me to enjoy life while feeling rejuvenated and empowered

For drugmakers, the findings highlight the need to position GLP-1s as long-term treatments for chronic disease versus fast weight loss solutions

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Theres also a lot of churn of people going on and off GLP-1s, and probably some noise in self-reported survey data