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The decision to use GLP-1 receptor agonists should be based on their licensed indications (diabetes or obesity management) rather than cholesterol lowering alone, with lipid improvements considered a beneficial additional effect within a comprehensive cardiovascular risk reduction strategy

Statistical analyses were performed using GraphPad Prism (version 9.0, GraphPad Software, San Diego, CA, USA)

To overcome these limitations, a number of pharmacological approaches have been developed over the past decades, but these drugs are generally of fairly limited efficacy, expensive and can in some cases cause significant side effects

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Structure GLP-3 (RT) Sequence : YAQGTFTSDYSILLDKKAQAAFIEYLLEGGPSSGAPPPS Note: Superscript numbers indicate specific chemical modifications enhancing stability and receptor activity