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Furthermore, compelling evidence implicates this local, brainstem-derived GLP-1, rather than gut-derived GLP-1, as a principal modulator of physiological GLP-1R dependent signals that regulate appetite and body weight (Drucker and Asa, 1988

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A., & Cazzola, R

Body weight reduction was 10.7% correcting for the small weight loss in the placebo group

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