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Studies have shown that bitter-tasting pharmaceuticals and substances, including polyphenols such as isosinensetin, bind to bitter taste receptors, and unlike other TAS2R agonists, stimulate GLP-1 secretion in NCI-H716 cells [192] (Fig

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December 4, 2020

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Conversely, participants receiving GLP-1 RAs were consistently more likely to report experiencing gastrointestinal side effects

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