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doi: 10.1124/mol.56.1.235

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In people with obesity and established cardiovascular disease but without diabetes, semaglutide 2.4 mg resulted in 20% reduction in major adverse cardiovascular events [(MACE), death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke] compared to placebo (SELECT trial) after a mean follow-up of 39.8 months this is the first trial demonstrating cardiovascular benefit for an obesity pharmacotherapy [110]

Although metformin did not alter the abovementioned gonadal parameters, it improved ovarian cyclicity, as manifested by the presence of two consecutive generations of corpora lutea, vs

10.1016/j.cmet.2006.01.004 [DOI] [PubMed] [Google Scholar] 12.Sesti G, Avogaro A, Belcastro S, Bonora BM, Croci M, Daniele G, et al

Lancet 2016;387(10027):15131530