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Between these two, metformin is our first-line preference as it helps not only with antipsychotic-related weight gain but also with the metabolic side effects of antipsychotics (insulin resistance, fasting glucose, triglycerides, and hyperprolactinemia), earning it a recommendation from the APA for this purpose

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Understanding the difference between these two active pharmaceutical ingredients helps patients have a more informed conversation with the reviewing provider during the intake process

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