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Why are GLP-1 medications so effective for weight loss

They deliver strong results for many people, yet bring high prices, needles, and frequent side effects

Journal of Clinical Endocrinology & Metabolism , 109(4), 12341246
Slower Movement Does Not Mean Simpler Operations There is a counterintuitive dynamic at work here that can be easy to miss

doi: 10.1111/dom.12824

in particular, one study reported the mechanism by which nucleus-tractus-solitarius-derived GLP-1 modulates neuronal activity and food intake behavior (through the following steps: GLP-1R signaling stimulates the PKA signaling pathway, which promotes phosphorylation of GluA1 S845, increasing GluA1 membrane trafficking and postsynaptic excitatory synaptic transmission), whereas alterations in the paraventricular nucleus of the hypothalamus GLP-1 signaling induced obesity [37]